Man in a thoughtful one-on-one consultation with a healthcare professional, representing discussion, evaluation, and guidance around the effects of stopping testosterone replacement therapy.

What Happens When You Stop Taking Testosterone Replacement Therapy

Testosterone Therapy
May 10th, 2022
1
Min Read

Article / What Happens When You Stop Taking Testosterone Replacement Therapy

Should you decide to stop testosterone replacement therapy, it can be tough to imagine how ending the treatment will make you feel. Every man who ends his treatment will experience unique side effects, especially when it is done the wrong way.

Side Effects of Stopping Testosterone

Any time your hormone balances shift, you should expect side effects to present themselves. Because testosterone is such a powerful hormone, ending treatment can adversely affect patients. Weight gain, muscle loss, headaches, and loss of sex drive are all potential outcomes. Because testosterone essentially lets your body operate at full speed, the comedown will typically put you back at your pre-treatment state (or lower). Once testosterone levels return to their naturally “low normal,” you will start to see the benefits diminish. Aside from the physical factors, dropping your levels may lead to depression, insomnia, loss of appetite, and lack of mental clarity, aka “brain fog”. Because there are often such positive benefits from testosterone replacement, the side effects can be equally negative once you stop treatment.

Weaning Off Testosterone Therapy

Some men are hit pretty hard when they try to stop taking testosterone, especially if their starting numbers were low. Depending on your current dosage, the side effects of stopping “cold turkey” can be pretty harsh, especially if your starting Testosterone levels were extremely low. Gradually reducing your testosterone intake over several weeks may be the safest way to end treatment without as many negative drawbacks. Slowly “weaning” yourself off of treatment will minimize the shock felt by your body through the process. Talk to a Testosterone treatment professional at Gameday Men’s Health to find the best way to end your treatment.

Using HCG and Proper Testosterone Support

Ending testosterone replacement therapy may leave you with some side effects, however pairing testosterone with HCG (Human chorionic gonadotropin) may help ease the process. HCG may help maintain natural testosterone levels and keep your testicles in good health, both of which are important for maintaining natural testosterone production and fertility, respectively. If you were not taking HCG while using Testosterone replacement therapy, speaking with a provider could reveal it to be a logical replacement to transition off of testosterone.

Consider a Structured TRT Discontinuation Program

So, what’s the best way to end your Testosterone treatment? Schedule a free consultation with a Gameday Men’s Health testosterone replacement therapy expert in your area to see how a custom tapering treatment can benefit you. These tailored plans help you avoid adverse side effects, stabilize your levels and keep you in great shape. Utilizing a TRT clinic allows you to formulate a safe an effective tapering program.

References Links

Testosterone Cypionate

Testosterone Cypionate provides long-acting hormone support through periodic injections that maintain steady testosterone levels. This option enhances muscle strength, bone health and overall vitality. Beneficial for men with confirmed hormone deficiency and performance-focused goals.

Read More...
SEE TREATMENT
SEE TREATMENT

Oral TRT (KYZATREX®)

This bioidentical oral testosterone formulation delivers stable hormone levels designed to restore energy, mood and masculine performance. It’s an ideal option for men seeking the convenience of a pill with the clinically proven benefits of medically supervised testosterone replacement.

Read More...
SEE TREATMENT
SEE TREATMENT

Testoterone Pellets

Testosterone pellets offer a slow-release solution for consistent hormone balance over months at a time. Once implanted beneath the skin, these pellets provide steady testosterone delivery, reducing the need for frequent dosing and helping men maintain energy, mood and drive with minimal disruption.

Read More...
SEE TREATMENT
SEE TREATMENT

Sermorelin

Sermorelin stimulates your body’s natural growth hormone production, supporting lean muscle growth, enhanced recovery, improved sleep and greater vitality. Ideal for men seeking a restorative, lifestyle-focused approach to aging well and maintaining energy, strength and overall wellness.

Read More...
SEE TREATMENT
SEE TREATMENT

Tirzepatide

Tirzepatide is a dual-action metabolic therapy that supports weight control by improving insulin sensitivity, reducing appetite, and enhancing satiety.
It helps regulate blood sugar levels and supports steady fat loss when combined with proper nutrition and lifestyle habits. This option is ideal for men seeking a guided, medically supervised approach to sustainable weight-management results.

Read More...
SEE TREATMENT
SEE TREATMENT

GLP-1 Therapy

GLP-1 therapy supports appetite regulation and blood sugar control to help men achieve steady, sustainable weight loss and improved metabolic health. For men who have tried diet and exercise yet still struggle with excess weight or energy dips, GLP-1 offers a medically-supervised option that aligns with performance, wellness and hormonal balance.

Read More...
SEE TREATMENT
SEE TREATMENT

SHOCKWAVE therapy

Shockwave therapy, also known as GainsWave®, uses low-intensity acoustic waves to stimulate new blood vessel growth and tissue regeneration. It’s a safe, non-invasive treatment that improves erectile function, sensation, and long-term performance without medication.

Read More...
SEE TREATMENT
SEE TREATMENT

Vitamin B12 injections

Vitamin B12 injections help boost energy, improve focus and support metabolic health by delivering a potent dose of this essential nutrient directly into your bloodstream. At Gameday we use B12 to support red blood cell and nerve health in men who feel fatigued or need a reliable vitality boost.

Read More...
SEE TREATMENT
SEE TREATMENT

MIC Lipotropic Injections

MIC Lipotropic injections deliver key nutrients designed to support fat metabolism, improve liver function and enhance overall energy. Ideal for men who train hard, travel often or need an extra metabolic boost, this therapy complements your lifestyle and helps your body make the most of your effort.

Read More...
SEE TREATMENT
SEE TREATMENT

P-Shot®

P-Shot® uses your body’s platelet-rich plasma to repair tissue, enhance blood flow, and increase sensitivity. This regenerative therapy supports stronger, longer-lasting erections while improving overall penile health and performance naturally.

Read More...
SEE TREATMENT
SEE TREATMENT
Fit man holding a Clomid pill bottle, highlighting treatment options for boosting testosterone and supporting men’s wellness.Fit man holding a Clomid pill bottle, highlighting treatment options for boosting testosterone and supporting men’s wellness.

Don’t just read about it, feel the difference.

Thousands of men have already taken the first step toward stronger energy, better performance, and lasting confidence. The science is real — and the results speak for themselves. Ready when you are.

Related Articles

A man running toward the future with the years 2024, 2025, and 2026 on the road, symbolizing progress in testosterone therapy as he moves toward improved health supported by a TRT clinic.

Kickstart 2026 Wellness: Elevate Men's Health with Gameday

As the new year approaches, focus on setting meaningful health goals. Embrace personalized wellness plans to unlock your best self and achieve optimal performance in 2026.
Read article
Read article
A man happily standing on a mountain peak, symbolizing renewed confidence and a fresh start thanks to effective ED treatment options for 2026.

Erectile Dysfunction Treatment Options to Start 2026 on a High Note

Explore the best erectile dysfunction treatment options for 2026, including medications, TRT, shockwave therapy, peptides, and more. Learn how to choose the right plan.
Read article
Read article
Man and woman smiling while lying on a bed, representing improved intimacy through natural ED treatments.

Natural Treatment for Erectile Dysfunction: What Works and What Doesn’t

Explore the best natural treatments for erectile dysfunction, including diet, exercise, supplements, stress reduction, and more. Learn when natural remedies help — and when to see a professional.
Read article
Read article
A man sits with a smile while two healthcare professionals discuss treatment options on a tablet, highlighting the personalized care and attention in choosing a testosterone replacement therapy clinic.

Your Health Matters: Choosing a Testosterone Replacement Therapy Clinic

Have you been feeling tired, find it difficult to sleep, or have a low sex drive? For many men in their late 30s and older, these can be common symptoms associated with low testosterone levels. Also known as low T, this hormonal imbalance can impact several important aspects of your health and your life.
Read article
Read article
A close-up of unhealthy foods like fried chicken, burgers, and sugary drinks that contribute to poor blood circulation and worsen erectile dysfunction symptoms in men.

Worst Foods for Erectile Dysfunction: What to Avoid for Better Performance

Learn which foods can worsen erectile dysfunction. Discover how diet affects blood flow, hormone balance, and performance — and what to eat instead.
Read article
Read article
Man at desk smiling while on phone with notepad in hand.

Why Office Workers Trust Gameday for Testosterone Therapy

Testosterone therapy can help office workers combat symptoms of low testosterone caused by sedentary lifestyles. Learn how it boosts energy, mood, and performance.
Read article
Read article
A muscular man preparing a testosterone injection, representing the importance of safe, medically supervised testosterone replacement therapy.

Why Is Testosterone a Controlled Substance? Understanding the Law and Safety

Learn why testosterone is a controlled substance, how it’s regulated, and why medical supervision is essential for safe and legal TRT.
Read article
Read article
Military man in casual wear relaxing on couch with dog in a warm, cozy room.

How Gameday’s TRT Empowers Military Members

Military personnel facing low testosterone can see improved strength, endurance, and mental sharpness through testosterone therapy. Understand its benefits and find tailored treatment options to boost performance and quality of life.
Read article
Read article
A young man sits on a bed, hand on head, reflecting on ED in young men, with a woman blurred in the background.

ED in Young Men: Overcoming Performance Anxiety and Regaining Confidence

For younger men experiencing ED, psychological factors can negatively impact sexual performance. Read about how to overcome performance anxiety in the bedroom.
Read article
Read article
Runner in a red jacket jogs through a snowy forest, an ideal scene for winter weight loss.

Unlock Winter Weight Loss with Gameday Men’s Health Solutions for Men

Winter weight gain is a common struggle for many men, but Gameday makes it easy to lose those stubborn pounds with personalized weight loss treatments.
Read article
Read article
Man in good shape stretching, highlighting fitness and weight loss benefits linked with GLP-1 treatments.

Which GLP-1 Is Best for Weight Loss?

GLP-1 medications have quickly become one of the most talked-about breakthroughs in medical weight loss. Originally developed for type 2 diabetes, these injectable treatments have recently been utilized to help patients shed significant weight while improving their metabolic health.
Read article
Read article
Two men stretching outdoors before a workout as a part of their weight loss journey combined with weight loss injections.

What is the Best Injection for Weight Loss? A Men’s Guide

For decades, the weight loss industry has pushed crash diets, endless cardio, and overpriced supplements. Most men who have struggled with weight loss have tried at least one of these “solutions,” only to watch the weight return over time. However, a new approach has been gaining attention in recent years: weight loss injections. When supported by clinical research and administered under medical supervision, these treatments are helping men lose fat more effectively than most fad diets ever could.
Read article
Read article