Two men resting after a pickleball game on an outdoor court, representing lifestyle changes and activity levels discussed in how soon semaglutide works for weight loss and metabolic health.

How Soon Does Semaglutide Work?

Weight Loss
Sep 13th, 2024
1
Min Read

Article / How Soon Does Semaglutide Work?

How Soon Does GLP-1 Work?

GLP-1 is an FDA-approved drug to promote weight loss in people who are considered obese and/or overweight. Many individuals will notice a decline in weight 4 or more weeks after treatment begins on a dose of .25 mg.While Semaglutide has previously been used for individuals with diabetes, it is known for being effective at helping overweight individuals lose weight safely. Learn more about the benefits of Semaglutide, the factors affecting how soon it can work, and whether or not you are a candidate for treatment.

How Quickly Does GLP-1 Work for Weight Loss?

It often is not until 4 or more weeks on a dose of 25 units + that patients will start to see a decline in weight. It’s possible that some individuals might not notice weight loss until close to 6 weeks.To enhance the benefits of Semaglutide, it’s recommended to combine the weekly injections with exercise and changes in diet. The exact amount of time you might need to receive this treatment will depend on your current health conditions (if any) and if exercise and dietary changes can be adopted permanently to maintain an ideal weight. For example, one study found that when GLP-1 is combined with a low-calorie diet and behavioral therapy, it results in an even more significant amount of weight loss.GLP-1 (glucagon-like-peptide-1), a receptor agonist, which means that it mimics the hormone GLP-1 known for regulating hunger, and therefore food intake. When GLP-1 is injected weekly, the hormone is suppressed and gastric emptying is delayed, which results in you feeling much more full and satisfied after eating a meal.

Factors Affecting How Soon It Will Work

The effectiveness and how quickly Semaglutide works can be influenced by several factors:

  • Dosage: Higher doses could lead to faster results but with increased risk of side effects.
  • Individual Metabolism: People's bodies process medications differently, affecting how quickly they notice weight loss.
  • Diet and Exercise: Lifestyle changes complement the drug's effectiveness, potentially enhancing the results.
  • Severity of Condition: Those with mild issues might notice improvements sooner than those with more severe conditions.
  • Adherence to Treatment: Consistency in taking the injections as prescribed is important for noticing the benefits within a 4 to 6-week (or longer) period of time.
  • Combination with Other Medications: Interactions with other drugs can affect how quickly Semaglutide works.

Benefits

GLP-1 injections are known for offering numerous benefits, including:

  • Significantly reducing weight, especially when combined with following a healthy diet and exercising regularly
  • Providing consistent, safe weight loss over an extended period of time
  • Diminishing risk of heart and cardiovascular disease upon achieving a healthy weight
  • Helping you to look and feel healthier
  • Requiring only one injection per week (often for up to 16 weeks)

Who is a Candidate?

You might be a candidate for GLP-1 injections if the below applies to you. Your healthcare provider will conduct a thorough health evaluation during your initial consultation to determine if you are a candidate.

  • Individuals with type 2 diabetes for blood sugar control
  • Patients needing assistance with weight loss when diet and exercise are insufficient
  • Adults with obesity (BMI ≥30) or overweight (BMI ≥27) with at least one weight-related condition (e.g., hypertension, type 2 diabetes, dyslipidemia)

As mentioned, studies indicate that GLP-1 is most effective when combined with changes to diet and exercise. One study of 1,961 people found that in people with a BMI over 30 and who did not have diabetes, GLP-1 injections combined with exercise resulted in a mean decrease in body weight of 14.9% over 68 weeks. The placebo group saw only a 2.4% mean decrease in weight.This makes it important to have a willingness to incorporate a healthy diet and regular exercise into your life if you are considering beginning treatment.

What are Potential Side Effects?

The potential side effects will vary based on your current health but can include:

  • Nausea, vomiting, diarrhea
  • Stomach pain, constipation
  • Headaches
  • Fatigue
  • Low blood sugar (in people with diabetes)

Additional side effects, while very rare, can include thyroid tumors, pancreatitis, kidney problems, and gallbladder issues.

Do You Need Help With Weight Loss?

At Gameday, you are our priority. We make up for what other men’s clinics lack in enhancing your health and then take it one step further. We want you to be comfortable during your visit, so we welcome you to relax in our overstuffed chairs while watching sports on our flat-screen TVs.By receiving your Semaglutide treatments with Gameday, you get to feel confident knowing you’re working with one of the best medical providers for men’s health.

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References Links

Testosterone Cypionate

Testosterone Cypionate provides long-acting hormone support through periodic injections that maintain steady testosterone levels. This option enhances muscle strength, bone health and overall vitality. Beneficial for men with confirmed hormone deficiency and performance-focused goals.

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Oral TRT (KYZATREX®)

This bioidentical oral testosterone formulation delivers stable hormone levels designed to restore energy, mood and masculine performance. It’s an ideal option for men seeking the convenience of a pill with the clinically proven benefits of medically supervised testosterone replacement.

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Testoterone Pellets

Testosterone pellets offer a slow-release solution for consistent hormone balance over months at a time. Once implanted beneath the skin, these pellets provide steady testosterone delivery, reducing the need for frequent dosing and helping men maintain energy, mood and drive with minimal disruption.

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Sermorelin

Sermorelin stimulates your body’s natural growth hormone production, supporting lean muscle growth, enhanced recovery, improved sleep and greater vitality. Ideal for men seeking a restorative, lifestyle-focused approach to aging well and maintaining energy, strength and overall wellness.

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Tirzepatide

Tirzepatide is a dual-action metabolic therapy that supports weight control by improving insulin sensitivity, reducing appetite, and enhancing satiety.
It helps regulate blood sugar levels and supports steady fat loss when combined with proper nutrition and lifestyle habits. This option is ideal for men seeking a guided, medically supervised approach to sustainable weight-management results.

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GLP-1 Therapy

GLP-1 therapy supports appetite regulation and blood sugar control to help men achieve steady, sustainable weight loss and improved metabolic health. For men who have tried diet and exercise yet still struggle with excess weight or energy dips, GLP-1 offers a medically-supervised option that aligns with performance, wellness and hormonal balance.

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SHOCKWAVE therapy

Shockwave therapy, also known as GainsWave®, uses low-intensity acoustic waves to stimulate new blood vessel growth and tissue regeneration. It’s a safe, non-invasive treatment that improves erectile function, sensation, and long-term performance without medication.

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Vitamin B12 injections

Vitamin B12 injections help boost energy, improve focus and support metabolic health by delivering a potent dose of this essential nutrient directly into your bloodstream. At Gameday we use B12 to support red blood cell and nerve health in men who feel fatigued or need a reliable vitality boost.

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MIC Lipotropic Injections

MIC Lipotropic injections deliver key nutrients designed to support fat metabolism, improve liver function and enhance overall energy. Ideal for men who train hard, travel often or need an extra metabolic boost, this therapy complements your lifestyle and helps your body make the most of your effort.

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P-Shot®

P-Shot® uses your body’s platelet-rich plasma to repair tissue, enhance blood flow, and increase sensitivity. This regenerative therapy supports stronger, longer-lasting erections while improving overall penile health and performance naturally.

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