Male patient consulting with healthcare providers reviewing medical information, illustrating discussions around testosterone replacement therapy safety and why more men are choosing TRT.

Is TRT Safe? Why More Men Are Taking Testosterone

Testosterone Therapy
May 11th, 2022
1
Min Read

Article / Is TRT Safe? Why More Men Are Taking Testosterone

Low testosterone (known colloquially as “Low T”) in men has become quite an epidemic. Countless men across America – and the rest of the world – are being prescribed testosterone (either as an injection, gel, or skin patch) to restore their health and vitality. While the advantages and benefits of testosterone replacement therapy (TRT) are promising, is TRT safe for men?

Read on as this article details the nature of low T, why more men are being prescribed TRT and the safety concerns of TRT you should know about. You can learn about Low T on our page here or sign up for a free consultation.

WHAT IS LOW T AND WHAT CAUSES IT?

Testosterone is what makes a man, a man. It’s the primary androgenic steroid in humans, meaning it promotes the development of male sexual characteristics. Testosterone also plays a myriad of other physiological roles due to its anabolic properties.

Without adequate testosterone, even seemingly simple daily activities can become quite a chore. No man likes the feeling of crawling out of bed and having no energy or motivation to be productive. Sure, an occasional “lazy day” can serve as a nice respite from the daily grind, but when that becomes routine, something is off.

Low T can arise due to a variety of reasons, many of which act in insidious manners. For example, not sleeping enough and being chronically stressed out are two common factors that decrease testosterone in males. By the same token, drinking excessive alcohol and being obese can also reduce testosterones.

As you can see, lifestyle factors play a role in your testosterone levels. This is not to say that low T can also come about due to factors that are out of your control, such as a pituitary malfunction or an accident that critically damages your testicles.

It’s important to note that determining whether or not TRT will be safe for a man is something a skilled physician and and labwork will help determine. If you’re experiencing low T due to lifestyle factors, like poor diet, lack of sleep, and sedentary lifestyle, you should be proactive about changing those before resorting to TRT.

However, if you experience chronic low T despite living an otherwise healthy lifestyle, then you might be a good candidate for TRT (and it will be much safer).

INDICATIONS OF LOW T (TESTOSTERONE)

In past decades, males were less educated about testosterone. Many were not aware that low T could be the underlying cause of their debilitating symptoms.

Due to recent advances in our understanding of low T and its prevalence, endocrinologists and pharmaceutical companies alike have been more proactive about direct-to-consumer marketing. Men are becoming more aware that they should have their testosterone levels checked if they are experiencing specific symptoms. Having testosterone levels checked is pertinent for men over 30, as research suggests that testosterone levels start to decline right around this age.

But what exactly are the symptoms and signs that you might have low T?

Here’s an abridged list of what a man may experience from low T:

  • Erectile dysfunction (impotence)
  • Reduced libido/sex drive
  • Reduced muscle bulk and strength
  • Decreased energy (fatigue) despite adequate rest
  • Depression and anxiety
  • Poor concentration (brain fog) and recall
  • Small or shrinking testes
  • Loss of body and pubic hair
  • Low red blood cell count (anemia)
    Infertility
  • Brittle bones and general weakness
  • Body fat increase
  • Sleep apnea (or other sleep disorders)
  • Development of breast tissue (gynecomastia)

While you may exhibit several (or all) of these symptoms, it’s essential to confirm that you have low T with the appropriate blood work. As this article will discuss later, TRT is safest if you have low T.

For example, depression is a symptom of some mental disorders. If you were to treat a mental disorder with TRT, the results won’t be favorable.

If you’re experiencing low T symptoms, contact Gameday Men’s Health today. One of our licensed physicians can order the proper lab work for you. We will guide you through the process of restoring your testosterone to healthy levels if you have low T.

IS LOW T ON THE RISE?

While modern medicine and scientific research have given us a much clearer grasp of how the human endocrine system functions, it remains to be elucidated what is causing the rise in low T diagnosis. Some research suggests that low T is more common nowadays due to the rather sedentary lifestyle that many men lead, along with neglect for healthy food choices.

It’s also postulated that exposure to man-made toxins, like xenoestrogens found in various personal care products and environmental contaminants, may disrupt the human endocrine system.

Of course, we can’t rule out the fact that men these days are just more proactive about their health, as well as being more knowledgeable about how important testosterone is for their well-being. This is primarily due to an increase in male health clinics across the country and the uprise of social media – allowing doctors and pharmaceutical companies to connect with consumers in a more personable manner than ever before.

The issue of low T has ostensibly been an epidemic for quite some time; we are now just more proactive about treating it.

WHAT ARE THE POTENTIAL RISKS OF TRT?

Men with low T often have reservations about taking testosterone. Is TRT safe in the long run? What are the potential health risks of TRT? Let’s take a more in-depth look at these pressing concerns.

A relatively small number of males who start TRT will experience some initial side effects of testosterone use, such as oily skin, acne, breast swelling or inflammation, and night sweats. These tend to subside as TRT progresses.

For older men who are on long-lasting TRT, there appears to be at a slightly greater risk of metabolic issues, like high blood pressure and high cholesterol. Routine blood testing and medication adjustments can help avoid these issues.. Gameday specialists require periodic lab work with TRT patients to ensure metabolic and cardiovascular biomarkers are in-check, thereby reducing any potential health risks.

Ironically, the health risks of neglecting to treat low T are arguably more life-threatening than TRT itself. Longitudinal data suggests that males with lower testosterone generally have a shorter lifespan (i.e., are at a higher risk of all-cause mortality) than those with testosterone levels in the healthy range.

Due to advances in hormone replacement therapy and medications – like the bioidentical hormones prescribed by physicians at Gameday Men’s Health – many men find that the advantages of TRT far outweigh the potential drawbacks.

Ultimately, TRT should be a mutual decision made with your physician. Be wary of doctors and specialists who are quick to prescribe you TRT without first confirming the diagnosis through proper blood testing (and possibly medical imaging, if necessary).

At Gameday Men’s Health, each patient undergoes testing for Low T before being given a comprehensive consultation with a medical provider.

Additionally, Gameday always measure PSA levels and hematocrit before prescribing TRT. If your PSA is below 4.0, you can safely begin TRT. If your hematocrit is above 50, you will need to donate blood first before beginning TRT (this is to ensure safety and long-term success).

We are not just out to make a quick buck by taking advantage of males who don’t feel well. TRT is a significant life decision. Gameday physicians treat it as such by making it as safe and effective as possible.

IS TRT SAFE FOR YOU?

All in all, TRT will be much safer for you if you have accurate assessments for low T performed and are under the care of a knowledgeable licensed physician, such as the specialists at Gameday Men’s Health.

For example, feeling tired, depressed, and/or having a low sex drive doesn’t necessarily mean you have low T, nor is that adequate information to diagnosis low T. Blood testing is imperative to get to the root cause of your symptoms.

Furthermore, if your blood tests come back normal/healthy, chances are TRT isn’t going to treat the symptoms you’re experiencing. Taking testosterone in a case where you already have adequate endogenous testosterone production can be unsafe and exacerbate other health issues. Remember, always confirm the suspicion that you have low T with proper blood tests.

GETTING ACCURATE ASSESSMENTS FOR LOW T

Misinterpreted or inaccurate blood test results can lead to a false diagnosis of low T or potentially cause someone who has low T to go undiagnosed.

Testosterone levels naturally peak in the morning hours, between 7 AM and 10 AM. Therefore, you should try to have your levels checked during that time frame for proper accuracy.

You will likely need to confirm your initial blood work results with a follow-up blood test. The specialists at GameDay will help interpret your results and answer any questions you have. If you are diagnosed with low T, you should consider TRT – especially if the symptoms are reducing your quality of life.

ASK YOUR DOCTOR ABOUT YOUR CONCERNS

Before starting (and during) TRT, having a completely open line of communication between you and your physician is the most practical and straightforward way to ensure your safety. This is precisely why one of the core values at Gameday Men’s Health is direct, simple, and ongoing communication with our patients.

If you’re dealing with a physician who is giving you the runaround and not answering your questions about the safety of TRT, they might not have your best interest in mind.

Here are some questions and concerns Gameday Men’s Health physicians often hear from prospective TRT patients:

  • Will TRT increase the risk of prostate cancer?
  • Is it ok to use testosterone despite having a history of cardiovascular complications?
  • Will I have to stay on TRT forever?
  • Which form of testosterone is best?

Contact us today and set up an initial consultation. We will be more than happy to answer any questions or concerns you have about TRT.

HAVE REALISTIC EXPECTATIONS ABOUT TRT

TRT at Gameday Men’s Health is designed to return you to high-functioning levels, both physically and mentally. Men with low T may experience a range of benefits as part of TRT, including an increase in libido, better erectile function, enhanced vitality and energy, improved lean body mass, and more precise mental focus. For the vast majority of men, TRT helps them feel healthy, happy and motivated again.

References Links

Testosterone Cypionate

Testosterone Cypionate provides long-acting hormone support through periodic injections that maintain steady testosterone levels. This option enhances muscle strength, bone health and overall vitality. Beneficial for men with confirmed hormone deficiency and performance-focused goals.

Read More...
SEE TREATMENT
SEE TREATMENT

Oral TRT (KYZATREX®)

This bioidentical oral testosterone formulation delivers stable hormone levels designed to restore energy, mood and masculine performance. It’s an ideal option for men seeking the convenience of a pill with the clinically proven benefits of medically supervised testosterone replacement.

Read More...
SEE TREATMENT
SEE TREATMENT

Testoterone Pellets

Testosterone pellets offer a slow-release solution for consistent hormone balance over months at a time. Once implanted beneath the skin, these pellets provide steady testosterone delivery, reducing the need for frequent dosing and helping men maintain energy, mood and drive with minimal disruption.

Read More...
SEE TREATMENT
SEE TREATMENT

Sermorelin

Sermorelin stimulates your body’s natural growth hormone production, supporting lean muscle growth, enhanced recovery, improved sleep and greater vitality. Ideal for men seeking a restorative, lifestyle-focused approach to aging well and maintaining energy, strength and overall wellness.

Read More...
SEE TREATMENT
SEE TREATMENT

Tirzepatide

Tirzepatide is a dual-action metabolic therapy that supports weight control by improving insulin sensitivity, reducing appetite, and enhancing satiety.
It helps regulate blood sugar levels and supports steady fat loss when combined with proper nutrition and lifestyle habits. This option is ideal for men seeking a guided, medically supervised approach to sustainable weight-management results.

Read More...
SEE TREATMENT
SEE TREATMENT

GLP-1 Therapy

GLP-1 therapy supports appetite regulation and blood sugar control to help men achieve steady, sustainable weight loss and improved metabolic health. For men who have tried diet and exercise yet still struggle with excess weight or energy dips, GLP-1 offers a medically-supervised option that aligns with performance, wellness and hormonal balance.

Read More...
SEE TREATMENT
SEE TREATMENT

SHOCKWAVE therapy

Shockwave therapy, also known as GainsWave®, uses low-intensity acoustic waves to stimulate new blood vessel growth and tissue regeneration. It’s a safe, non-invasive treatment that improves erectile function, sensation, and long-term performance without medication.

Read More...
SEE TREATMENT
SEE TREATMENT

Vitamin B12 injections

Vitamin B12 injections help boost energy, improve focus and support metabolic health by delivering a potent dose of this essential nutrient directly into your bloodstream. At Gameday we use B12 to support red blood cell and nerve health in men who feel fatigued or need a reliable vitality boost.

Read More...
SEE TREATMENT
SEE TREATMENT

MIC Lipotropic Injections

MIC Lipotropic injections deliver key nutrients designed to support fat metabolism, improve liver function and enhance overall energy. Ideal for men who train hard, travel often or need an extra metabolic boost, this therapy complements your lifestyle and helps your body make the most of your effort.

Read More...
SEE TREATMENT
SEE TREATMENT

P-Shot®

P-Shot® uses your body’s platelet-rich plasma to repair tissue, enhance blood flow, and increase sensitivity. This regenerative therapy supports stronger, longer-lasting erections while improving overall penile health and performance naturally.

Read More...
SEE TREATMENT
SEE TREATMENT
Fit man holding a Clomid pill bottle, highlighting treatment options for boosting testosterone and supporting men’s wellness.Fit man holding a Clomid pill bottle, highlighting treatment options for boosting testosterone and supporting men’s wellness.

Don’t just read about it, feel the difference.

Thousands of men have already taken the first step toward stronger energy, better performance, and lasting confidence. The science is real — and the results speak for themselves. Ready when you are.

Related Articles

A man running toward the future with the years 2024, 2025, and 2026 on the road, symbolizing progress in testosterone therapy as he moves toward improved health supported by a TRT clinic.

Kickstart 2026 Wellness: Elevate Men's Health with Gameday

As the new year approaches, focus on setting meaningful health goals. Embrace personalized wellness plans to unlock your best self and achieve optimal performance in 2026.
Read article
Read article
A man happily standing on a mountain peak, symbolizing renewed confidence and a fresh start thanks to effective ED treatment options for 2026.

Erectile Dysfunction Treatment Options to Start 2026 on a High Note

Explore the best erectile dysfunction treatment options for 2026, including medications, TRT, shockwave therapy, peptides, and more. Learn how to choose the right plan.
Read article
Read article
Man and woman smiling while lying on a bed, representing improved intimacy through natural ED treatments.

Natural Treatment for Erectile Dysfunction: What Works and What Doesn’t

Explore the best natural treatments for erectile dysfunction, including diet, exercise, supplements, stress reduction, and more. Learn when natural remedies help — and when to see a professional.
Read article
Read article
A man sits with a smile while two healthcare professionals discuss treatment options on a tablet, highlighting the personalized care and attention in choosing a testosterone replacement therapy clinic.

Your Health Matters: Choosing a Testosterone Replacement Therapy Clinic

Have you been feeling tired, find it difficult to sleep, or have a low sex drive? For many men in their late 30s and older, these can be common symptoms associated with low testosterone levels. Also known as low T, this hormonal imbalance can impact several important aspects of your health and your life.
Read article
Read article
A close-up of unhealthy foods like fried chicken, burgers, and sugary drinks that contribute to poor blood circulation and worsen erectile dysfunction symptoms in men.

Worst Foods for Erectile Dysfunction: What to Avoid for Better Performance

Learn which foods can worsen erectile dysfunction. Discover how diet affects blood flow, hormone balance, and performance — and what to eat instead.
Read article
Read article
Man at desk smiling while on phone with notepad in hand.

Why Office Workers Trust Gameday for Testosterone Therapy

Testosterone therapy can help office workers combat symptoms of low testosterone caused by sedentary lifestyles. Learn how it boosts energy, mood, and performance.
Read article
Read article
Military man in casual wear relaxing on couch with dog in a warm, cozy room.

How Gameday’s TRT Empowers Military Members

Military personnel facing low testosterone can see improved strength, endurance, and mental sharpness through testosterone therapy. Understand its benefits and find tailored treatment options to boost performance and quality of life.
Read article
Read article
A muscular man preparing a testosterone injection, representing the importance of safe, medically supervised testosterone replacement therapy.

Why Is Testosterone a Controlled Substance? Understanding the Law and Safety

Learn why testosterone is a controlled substance, how it’s regulated, and why medical supervision is essential for safe and legal TRT.
Read article
Read article
A young man sits on a bed, hand on head, reflecting on ED in young men, with a woman blurred in the background.

ED in Young Men: Overcoming Performance Anxiety and Regaining Confidence

For younger men experiencing ED, psychological factors can negatively impact sexual performance. Read about how to overcome performance anxiety in the bedroom.
Read article
Read article
Runner in a red jacket jogs through a snowy forest, an ideal scene for winter weight loss.

Unlock Winter Weight Loss with Gameday Men’s Health Solutions for Men

Winter weight gain is a common struggle for many men, but Gameday makes it easy to lose those stubborn pounds with personalized weight loss treatments.
Read article
Read article
Man in good shape stretching, highlighting fitness and weight loss benefits linked with GLP-1 treatments.

Which GLP-1 Is Best for Weight Loss?

GLP-1 medications have quickly become one of the most talked-about breakthroughs in medical weight loss. Originally developed for type 2 diabetes, these injectable treatments have recently been utilized to help patients shed significant weight while improving their metabolic health.
Read article
Read article
Two men stretching outdoors before a workout as a part of their weight loss journey combined with weight loss injections.

What is the Best Injection for Weight Loss? A Men’s Guide

For decades, the weight loss industry has pushed crash diets, endless cardio, and overpriced supplements. Most men who have struggled with weight loss have tried at least one of these “solutions,” only to watch the weight return over time. However, a new approach has been gaining attention in recent years: weight loss injections. When supported by clinical research and administered under medical supervision, these treatments are helping men lose fat more effectively than most fad diets ever could.
Read article
Read article